Journal article
Nuclear SIRT1 activity, but not protein content, regulates mitochondrial biogenesis in rat and human skeletal muscle
Abstract
Silent mating type information regulator 2 homolog 1 (SIRT1)-mediated peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) deacetylation is potentially key for activating mitochondrial biogenesis. Yet, at the whole muscle level, SIRT1 is not associated with mitochondrial biogenesis (Gurd, BJ, Yoshida Y, Lally J, Holloway GP, Bonen A. J Physiol 587: 1817-1828, 2009). Therefore, we examined nuclear SIRT1 protein and activity …
Authors
Gurd BJ; Yoshida Y; McFarlan JT; Holloway GP; Moyes CD; Heigenhauser GJF; Spriet L; Bonen A
Journal
AJP Regulatory Integrative and Comparative Physiology, Vol. 301, No. 1, pp. r67–r75
Publisher
American Physiological Society
Publication Date
July 2011
DOI
10.1152/ajpregu.00417.2010
ISSN
0363-6119
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AMP-Activated Protein KinasesAminoimidazole CarboxamideAnimalsCell NucleusExerciseFemaleHeat-Shock ProteinsHumansHypoglycemic AgentsMaleMitochondria, MuscleModels, AnimalMuscle ContractionMuscle, SkeletalPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPhysical Conditioning, AnimalRNA-Binding ProteinsRatsRats, Sprague-DawleyRibonucleotidesSirtuin 1Transcription Factors