Journal article
Inhibition and Activation of Human Lactate Dehydrogenase by Urea
Abstract
The degree of inhibition or activation at 37°C by urea of human lactate dehydrogenase isoenzymes has been established with pyruvate, 2-oxobutyrate, and hydroxypvruvate as substrates. Lactate dehydrogenase activation has been demonstrated in the presence of low concentrations of urea. The protective effect of urea against enzyme inhibition by increased substrate concentrations has also been confirmed. Clinical studies indicate that urea …
Authors
McQueen MJ
Journal
Annals of Clinical Biochemistry International Journal of Laboratory Medicine, Vol. 11, No. 1-6, pp. 75–80
Publisher
SAGE Publications
Publication Date
January 1974
DOI
10.1177/000456327401100131
ISSN
0004-5632