Journal article
Characterization of the prostanoid TP receptor population in human nonpregnant myometrium.
Abstract
We have used both functional and binding studies to fully characterize the prostanoid TP receptor in the myometrium from nonpregnant human donors. Both U-46,619 and I-BOP produced concentration-dependent contraction of human myometrial strips in vitro (pEC50 = 6.9 +/- 0.6; and 7.8 +/- 0.5, respectively). U-46,619-induced contractions were attenuated by the TP receptor antagonists: ICI 192,605 (pKB = 9.2 +/- 0.3); ICI D1,542 (pKB = 9.1 +/- 0.3); …
Authors
Senchyna M; Crankshaw DJ
Journal
Journal of Pharmacology and Experimental Therapeutics, Vol. 279, No. 1, pp. 262–270
Publisher
Elsevier
Publication Date
10 1996
DOI
10.1016/s0022-3565(25)20963-6
ISSN
0022-3565
Fields of Research (FoR)
Medical Subject Headings (MeSH)
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic AcidAdultBinding, CompetitiveBridged Bicyclo Compounds, HeterocyclicDose-Response Relationship, DrugFatty Acids, UnsaturatedFemaleGuanosine 5'-O-(3-Thiotriphosphate)HumansIn Vitro TechniquesMiddle AgedMyometriumProstaglandin Endoperoxides, SyntheticReceptors, ThromboxaneThromboxane A2