Journal article
Accumulation of the inositol phosphates in thrombin-stimulated, washed rabbit platelets in the presence of lithium
Abstract
Experiments with washed rabbit platelets demonstrate that stimulation with a low concentration of thrombin (0.1 unit/ml), that causes maximal aggregation and partial release of amine granule contents, also causes increased accumulation of [3H]inositol-labelled inositol trisphosphate (InsP3) in the presence of 20 mM-Li+. This concentration of Li+ was found to inhibit the degradation of inositol phosphates by phosphomonoesterases. This result …
Authors
Vickers JD; Kinlough-Rathbone RL; Mustard JF
Journal
Biochemical Journal, Vol. 224, No. 2, pp. 399–405
Publisher
Portland Press
Publication Date
December 1, 1984
DOI
10.1042/bj2240399
ISSN
0264-6021