Journal article
Montelukast Treatment Attenuates the Increase in Myofibroblasts Following Low-Dose Allergen Challenge
Abstract
RATIONALE: Airway remodeling is believed to be important in the pathophysiology of asthma, and myofibroblasts are increased in the airways of asthmatic individuals 24 h after allergen challenge. Leukotriene receptor antagonists exert antiinflammatory activity in asthma, but it is unknown whether they influence indices of airway remodeling. In the present study, we evaluated the effect of montelukast on airway myofibroblasts following low-dose …
Authors
Kelly MM; Chakir J; Vethanayagam D; Boulet L-P; Laviolette M; Gauldie J; O'Byrne PM
Journal
Chest, Vol. 130, No. 3, pp. 741–753
Publisher
Elsevier
Publication Date
September 2006
DOI
10.1378/chest.130.3.741
ISSN
0012-3692