Protein Resistance of Surfaces Prepared by Sorption of End-Thiolated Poly(ethylene glycol) to Gold: Effect of Surface Chain Density

Nonspecific protein adsorption generally occurs at the biomaterial-tissue interface and usually has adverse consequences. Thus, surfaces that are protein-resistant are eagerly sought with the expectation that these materials will exhibit improved biocompatibility. Surfaces modified with end-tethered poly(ethylene oxide) (PEO) have been shown to be protein-resistant to some degree. Although the mechanisms are unclear, it has been suggested that …