Journal article
PNIPAAm-Grafted-Collagen as an Injectable, In Situ Gelling, Bioactive Cell Delivery Scaffold
Abstract
We synthesized two thermoresponsive, bioactive cell scaffolds by decorating the backbone of type I bovine collagen with linear chains of poly(N-isopropylacrylamide) (PNIPAAm), with the ultimate aim of providing facile delivery via injection and support of retinal pigment epithelial (RPE) cells into the back of the eye for the treatment of retinal degenerative diseases. Both scaffolds displayed rapid, subphysiological phase transition …
Authors
Fitzpatrick SD; Mazumder MAJ; Lasowski F; Fitzpatrick LE; Sheardown H
Journal
Biomacromolecules, Vol. 11, No. 9, pp. 2261–2267
Publisher
American Chemical Society (ACS)
Publication Date
September 13, 2010
DOI
10.1021/bm100299j
ISSN
1525-7797