Journal article
AIT-082, a unique purine derivative, enhances nerve growth factor mediated neurite outgrowth from PC12 cells
Abstract
AIT-082 is a novel, metabolically stable, derivative of the purine hypoxanthine. Addition of AIT-082 to cultured PC12 cells enhanced significantly nerve growth factor (NGF)-mediated neurite outgrowth from PC12 cells. These results suggest a cellular mechanism, the enhancement of NGF-action, that might account for the ability of AIT-082 to restore age-induced working memory deficits in mice.
Authors
Middlemiss PJ; Glasky AJ; Rathbone MP; Werstuik E; Hindley S; Gysbers J
Journal
Neuroscience Letters, Vol. 199, No. 2, pp. 131–134
Publisher
Elsevier
Publication Date
October 1995
DOI
10.1016/0304-3940(95)12029-4
ISSN
0304-3940