Journal article
Role of lipoxygenase metabolism in platelet function: Effect of aspirin and salicylate
Abstract
Aspirin inhibits thromboxane A2 (TxA2) production whereas its salicylate moiety inhibits 12-hydroxy-eicosatetraenoic acid (12-HETE) production in the platelet. The significance of the latter effect on platelet function is unclear. We examined the effects of aspirin and salicylate on (i) platelet/collagen adhesion using 3H-adenine-labelled human platelets and collagen-coated discs, (ii) platelet aggregation induced by thrombin, collagen, ADP and …
Authors
Buchanan MR; Butt RW; Hirsh J; Markham BA; Nazir DJ
Journal
Prostaglandins Leukotrienes and Medicine, Vol. 21, No. 2, pp. 157–168
Publisher
Elsevier
Publication Date
February 1986
DOI
10.1016/0262-1746(86)90149-6
ISSN
0262-1746