Advances in antithrombotic drug therapy for coronary artery disease

Compounds which inhibit the coagulation cascade and antagonize platelet function are fundamental to the successful treatment of acute coronary syndromes. In a high proportion of patients with acute myocardial infarction, unstable angina, or sudden cardiac death, the acute ischaemic event is precipitated by intracoronary thrombus. Occlusive or non-occlusive thrombi have been found in the majority of cases, either in vivo or at autopsy. Aspirin …