Journal article
The Protective Mechanism of Fluorofenidone in Renal Interstitial Inflammation and Fibrosis
Abstract
BACKGROUND: Deregulated inflammation has been implicated in the development of renal interstitial fibrosis and progressive renal failure. Previous work has established that fluorofenidone, a pyridone agent, attenuates renal fibrosis. However, the mechanism by which fluorofenidone prevents renal fibrosis remains unclear. The aim of this study was to investigate the in vivo effects of fluorofenidone on unilateral ureteral obstruction-induced …
Authors
Tang Y; Zhang F; Huang L; Yuan Q; Qin J; Li B; Wang N; Xie Y; Wang L; Wang W
Journal
The American Journal of the Medical Sciences, Vol. 350, No. 3, pp. 195–203
Publisher
Elsevier
Publication Date
September 2015
DOI
10.1097/maj.0000000000000501
ISSN
0002-9629