Journal article
Ocular Gene Transfer of Active TGF-β Induces Changes in Anterior Segment Morphology and Elevated IOP in Rats
Abstract
Purpose. Transforming growth factor beta (TGF-beta) is known to play a crucial role in wound healing and fibrotic tissue remodeling. A large body of evidence suggests a role for this cytokine in the pathogenesis of glaucoma; however, the mechanisms by which it affects anterior segment morphology are not well understood. Therefore, the purpose of this study was to examine the effects of TGF-beta overexpression on anterior segment morphology and …
Authors
Robertson JV; Golesic E; Gauldie J; West-Mays JA
Journal
Investigative Ophthalmology & Visual Science, Vol. 51, No. 1, pp. 308–318
Publisher
Association for Research in Vision and Ophthalmology (ARVO)
Publication Date
January 1, 2010
DOI
10.1167/iovs.09-3380
ISSN
0146-0404
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
ActinsAdenoviridaeAnimalsAnterior Eye SegmentCadherinsCataractCollagen Type IVDisease Models, AnimalExtracellular MatrixFibrosisFluorescent Antibody Technique, IndirectGene ExpressionGenetic VectorsGreen Fluorescent ProteinsIn Situ Nick-End LabelingIntraocular PressureIridocorneal Endothelial SyndromeMaleMicroscopy, FluorescenceOcular HypertensionRatsRats, WistarRetinal DiseasesTonometry, OcularTrabecular MeshworkTransfectionTransforming Growth Factor beta1