Journal article
Selection and characterization of a DNA aptamer inhibiting coagulation factor XIa
Abstract
Factor XIa (FXIa) is a serine protease that catalyzes the activation of Factor IX (FIX) in the blood coagulation cascade. FXIa and its precursor FXI are emergent therapeutic targets for the development of safer anticoagulant agents. Here, we sought a novel DNA-based agent to inhibit FXIa. Towards this goal, an 80 base, single-stranded DNA aptamer library (containing a 40 base randomized core) was screened for FXIa-binding candidates, using ten …
Authors
Donkor DA; Bhakta V; Eltringham-Smith LJ; Stafford AR; Weitz JI; Sheffield WP
Journal
Scientific Reports, Vol. 7, No. 1,
Publisher
Springer Nature
DOI
10.1038/s41598-017-02055-x
ISSN
2045-2322