Journal article
Induction of a fibrogenic response in mouse colon by overexpression of monocyte chemoattractant protein 1
Abstract
BACKGROUND AND AIMS: Monocyte chemoattractant protein 1 (MCP-1) is increased transmurally in inflammatory bowel disease (IBD). Although MCP-1 is considered to play an important role in fibrotic disease in other organs, the role of MCP-1 in gut fibrosis is unknown. We investigated the fibrotic potential of MCP-1 in the gut by overexpressing this chemokine in the mouse colorectal wall.
METHODS: Intramural gene transfer by direct injection of …
Authors
Motomura Y; Khan WI; El-Sharkawy RT; Verma-Gandhu M; Verdu EF; Gauldie J; Collins SM
Journal
Gut, Vol. 55, No. 5,
Publisher
BMJ
Publication Date
May 1, 2006
DOI
10.1136/gut.2005.068429
ISSN
0017-5749
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdenoviridaeAnimalsChemokine CCL2Collagen Type ICollagen Type IIIColonEnzyme-Linked Immunosorbent AssayFibrosisGenetic VectorsHistocytochemistryImmunohistochemistryLymphocytesMaleMatrix Metalloproteinase 3MiceMice, Inbred C57BLMice, KnockoutRectumTissue Inhibitor of Metalloproteinase-1Transduction, GeneticTransforming Growth Factor beta