Journal article
Reactivation of Inflammatory Bowel Disease in a Mouse Model of Depression
Abstract
BACKGROUND & AIMS: Patients with inflammatory bowel disease (IBD) frequently also have depression, yet little is known of its role in IBD pathogenesis. We investigated whether the development of depression after the establishment of chronic inflammation reactivates an acute relapse of IBD and underlying pharmacologic mechanisms in mouse models.
METHODS: Colitis was induced by administration of dextran sulfate sodium (DSS) or …
Authors
Ghia J; Blennerhassett P; Deng Y; Verdu EF; Khan WI; Collins SM
Journal
Gastroenterology, Vol. 136, No. 7, pp. 2280–2288.e4
Publisher
Elsevier
Publication Date
6 2009
DOI
10.1053/j.gastro.2009.02.069
ISSN
0016-5085
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Analysis of VarianceAnimalsC-Reactive ProteinCells, CulturedColitisCytokinesDepressionDextran SulfateDisease Models, AnimalEnzyme-Linked Immunosorbent AssayImmunohistochemistryInflammation MediatorsInflammatory Bowel DiseasesIntestinal MucosaMacrophagesMaleMiceMice, Inbred C57BLProbabilityRandom AllocationSensitivity and SpecificitySeverity of Illness Index