Journal article
AMP-activated protein kinase (AMPK) β1β2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise
Abstract
AMP-activated protein kinase (AMPK) β1 or β2 subunits are required for assembling of AMPK heterotrimers and are important for regulating enzyme activity and cellular localization. In skeletal muscle, α2β2γ3-containing heterotrimers predominate. However, compensatory up-regulation and redundancy of AMPK subunits in whole-body AMPK α2, β2, and γ3 null mice has made it difficult to determine the physiological importance of AMPK in regulating …
Authors
O'Neill HM; Maarbjerg SJ; Crane JD; Jeppesen J; Jørgensen SB; Schertzer JD; Shyroka O; Kiens B; van Denderen BJ; Tarnopolsky MA
Journal
Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, No. 38, pp. 16092–16097
Publisher
Proceedings of the National Academy of Sciences
Publication Date
September 20, 2011
DOI
10.1073/pnas.1105062108
ISSN
0027-8424
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AMP-Activated Protein KinasesAnimalsDNA, MitochondrialFemaleGlucoseHypoglycemic AgentsImmunoblottingInsulinMaleMiceMice, Inbred C57BLMice, KnockoutMicroscopy, Electron, TransmissionMitochondria, MuscleMitochondrial ProteinsMuscle ContractionMuscle, SkeletalPhysical Conditioning, AnimalReverse Transcriptase Polymerase Chain Reaction