Journal article
A conformational landscape for alginate secretion across the outer membrane of Pseudomonas aeruginosa
Abstract
The exopolysaccharide alginate is an important component of biofilms produced by Pseudomonas aeruginosa, a major pathogen that contributes to the demise of cystic fibrosis patients. Alginate exits the cell via the outer membrane porin AlgE. X-ray structures of several AlgE crystal forms are reported here. Whilst all share a common β-barrel constitution, they differ in the degree to which loops L2 and T8 are ordered. L2 and T8 have been …
Authors
Tan J; Rouse SL; Li D; Pye VE; Vogeley L; Brinth AR; Arnaout TE; Whitney JC; Howell PL; Sansom MSP
Journal
Acta Crystallographica Section D, Structural Biology, Vol. 70, No. 8, pp. 2054–2068
Publisher
International Union of Crystallography (IUCr)
Publication Date
August 1, 2014
DOI
10.1107/s1399004714001850
ISSN
2059-7983