Journal article
Reduced NGF secretion by HT-29 human colon cancer cells treated with a GRPR antagonist.
Abstract
The gastrin-releasing peptide receptor (GRPR) is a therapeutic target in colon cancer. Here we show that the GRPR antagonist RC-3095 (10(-3), 10(-6), or 1 microM) decreases nerve growth factor (NGF) secretion measured by enzyme-linked immunosorbent assay (ELISA) in HT-29 human colon carcinoma cells. The results suggest that decreased secretion of neurotrophins might be a novel mechanism by which GRPR antagonists exert their antiproliferative …
Authors
de Farias CB; Stertz L; Lima RC; Kapczinski F; Schwartsmann G; Roesler R
Journal
Protein and Peptide Letters, Vol. 16, No. 6, pp. 650–652
Publisher
Bentham Science Publishers
Publication Date
2009
DOI
10.2174/092986609788490177
ISSN
0929-8665