Journal article
Alginate as an auxiliary bacterial membrane: binding of membrane‐active peptides by polysaccharides*
Abstract
The chronicity of Pseudomonas aeruginosa infections in cystic fibrosis (CF) patients is characterized by overproduction of the exopolysaccharide alginate, in which biofilm bacteria are embedded. Alginate apparently contributes to the antibiotic resistance of bacteria in this form by acting as a diffusion barrier to positively charged antimicrobial agents. We have been investigating cationic antimicrobial peptides (CAPs) (prototypic sequence: …
Authors
Chan C; Burrows LL; Deber CM
Journal
Chemical Biology & Drug Design, Vol. 65, No. 3, pp. 343–351
Publisher
Wiley
Publication Date
March 2005
DOI
10.1111/j.1399-3011.2005.00217.x
ISSN
1747-0277