Journal article
Role of proteolysis in apoptosis: involvement of serine proteases in internucleosomal DNA fragmentation in immature thymocytes
Abstract
Three chemically distinct serine, but not cysteine, protease inhibitors (phenylmethylsulphonyl fluoride, N-tosyl-L-phenylalanylchloromethyl ketone and 3,4-dichloroisocoumarin) prevented, in a dose-dependent manner, the characteristic apoptotic internucleosomal DNA cleavage (DNA ladder) typically observed in thymocytes in response to dexamethasone and teniposide VM-26. This effect was not the result of a direct inhibition of the …
Authors
Weaver VM; Lach B; Walker PR; Sikorska M
Journal
Biochemistry and Cell Biology, Vol. 71, No. 9-10, pp. 488–500
Publisher
Canadian Science Publishing
Publication Date
September 1, 1993
DOI
10.1139/o93-071
ISSN
0829-8211