Journal article
Common polymorphisms of cyclooxygenase-2 and prostaglandin E2 receptor and increased risk for acute coronary syndrome in coronary artery disease
Abstract
The arachidonic acid metabolites participate in development of coronary artery disease (CAD) and the plaque's instability. We assessed two common genetic polymorphisms: of cyclooxygenase-2 (COX-2) (COX2.8473, rs5275) and prostaglandin EP2 receptor gene (uS5, rs708494) in patients with CAD. Out of 1,368 patients screened by coronary arteriography, two groups fulfilled the entry criteria and were studied: stable coronary disease (sCAD, n = 125) …
Authors
Szczeklik W; Sanak M; Rostoff P; Piwowarska W; Jakiela B; Szczeklik A
Journal
Thrombosis and Haemostasis, Vol. 100, No. 05, pp. 893–898
Publisher
Thieme
Publication Date
2008
DOI
10.1160/th08-05-0282
ISSN
0340-6245
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Acute Coronary SyndromeAdultAgedAged, 80 and overCase-Control StudiesCoronary Artery DiseaseCyclooxygenase 1Cyclooxygenase 2DinoprostoneFemaleGene Expression Regulation, EnzymologicGene FrequencyGenetic Predisposition to DiseaseHumansMaleMiddle AgedMonocytesPhenotypePolymorphism, GeneticProspective StudiesReceptors, Prostaglandin EReceptors, Prostaglandin E, EP2 SubtypeRisk AssessmentRisk Factors