Journal article
Intrathecal administration of CGRP in the rat attenuates a facilitation of the tail flick reflex induced by either substance P or noxious cutaneous stimulation
Abstract
Intrathecal (i.t.) administration of substance P in the awake rat decreases reaction time (RT) in the tail flick test. In the anaesthetized rat, noxious thermal stimulation of the tail (by immersion of tip in water at 55 degrees C) also decreases RT; this effect is blocked by a substance P antagonist. The present study examines the effects of calcitonin gene-related peptide (CGRP) on the decrease in RT produced in these two paradigms. …
Authors
Cridland RA; Henry JL
Journal
Neuroscience Letters, Vol. 102, No. 2-3, pp. 241–246
Publisher
Elsevier
Publication Date
July 1989
DOI
10.1016/0304-3940(89)90085-2
ISSN
0304-3940