Journal article
Intrathecal administration of calcitonin gene-related peptide (CGRP) increases heart rate and decreases arterial pressure in the urethane anesthetized rat
Abstract
Intrathecal administration of CGRP (2.15-8.60 nmol) to the ninth thoracic vertebral segment of the spinal cord in the urethane anesthetized rat provoked an increase in heart rate (peak effect of 72 bpm) and a decrease in arterial pressure (maximum fall of 15 mmHg). Administration of CGRP to the T2 level (n = 10) or intravenously (n = 6) produced qualitatively and quantitatively similar effects to those observed following administration to the …
Authors
Rochford J; Yashpal K; Henry JL
Journal
Brain Research Bulletin, Vol. 25, No. 6, pp. 809–816
Publisher
Elsevier
Publication Date
12 1990
DOI
10.1016/0361-9230(90)90175-y
ISSN
0361-9230