Journal article
Dynamics of Dnmt1 Methyltransferase Expression and Intracellular Localization during Oogenesis and Preimplantation Development
Abstract
The imprinting of mammalian genes depends on the maintenance of DNA methylation patterns during pre- and postimplantation development. Dnmt1o is a variant form of the somatically expressed Dnmt1 cytosine methyltransferase that is synthesized and stored in the oocyte cytoplasm and trafficks to the eight-cell nucleus during preimplantation development, where it maintains DNA methylation patterns on alleles of imprinted genes. Transcripts encoding …
Authors
Ratnam S; Mertineit C; Ding F; Howell CY; Clarke HJ; Bestor TH; Chaillet JR; Trasler JM
Journal
Developmental Biology, Vol. 245, No. 2, pp. 304–314
Publisher
Elsevier
Publication Date
May 2002
DOI
10.1006/dbio.2002.0628
ISSN
0012-1606
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Alternative SplicingAmino Acid SequenceAnimalsBase SequenceBlastocystCloning, MolecularDNA (Cytosine-5-)-Methyltransferase 1DNA (Cytosine-5-)-MethyltransferasesEmbryonic and Fetal DevelopmentGene Expression Regulation, DevelopmentalIsoenzymesMiceMolecular Sequence DataOocytesOogenesisOrgan SpecificityProtein TransportRNA, MessengerReverse Transcriptase Polymerase Chain ReactionSex Characteristics