Heterogeneity in spontaneous and tetraethylammonium induced intracellular electrical activity in colonic circular muscle

Marked differences were observed in the intracellular electrical activities (spontaneous and TEA-induced) comparing the submucosal and myenteric plexus surfaces of the circular muscle of the dog colon. Distinct characteristics of the cells at the myenteric plexus surface were: a less (10 mV) polarized membrane, a lower amplitude slow wave, and the occurrence of burst type spiking activity. However, slow waves with a high upstroke amplitude …