Journal article
Quinidine and quinine effects on the slow wave activity of colonic circular muscle
Abstract
The slow wave plateau phase has an important role in the regulation of contractile activity in the canine colon. Quinidine (EC50 approximately 5 microM) and quinine (EC50 approximately 13 microM) inhibited in a concentration dependent manner the plateau phase. Quinidine and quinine decreased the plateau amplitude, and increased the plateau potential; whereas, they did not affect the upstroke amplitude, and the average rate of rise of the slow …
Authors
Barajas-López C; Huizinga JD
Journal
European Journal of Pharmacology, Vol. 163, No. 1, pp. 137–140
Publisher
Elsevier
Publication Date
4 1989
DOI
10.1016/0014-2999(89)90407-x
ISSN
0014-2999