Mitochondrial dysfunction is associated with increased oxidative stress and inflammation, and Nrf2‐mediated antioxidant dysregulation with frail aging

We previously reported that inactive frail old (FO) subjects exhibit mitochondrial DNA damage and ETC dysfunction vs. physically active young and old (AO) subjects (Safdar et al, 2006). We now investigate whether these observations are associated with changes in oxidative stress, inflammation and a nuclear factor erythroid 2‐related factor 2 (Nrf2)‐mediated antioxidant response. Muscle biopsies were taken from the vastus lateralis of young …