Journal article
The Murine Double-Stranded RNA-Dependent Protein Kinase PKR Is Required for Resistance to Vesicular Stomatitis Virus
Abstract
Interferon (IFN)-induced antiviral responses are mediated through a variety of proteins, including the double-stranded RNA-dependent protein kinase PKR. Here we show that fibroblasts derived from PKR(-/-) mice are more permissive for vesicular stomatitis virus (VSV) infection than are wild-type fibroblasts and demonstrate a deficiency in alpha/beta-IFN-mediated protection. We further show that mice lacking PKR are extremely susceptible to …
Authors
Stojdl DF; Abraham N; Knowles S; Marius R; Brasey A; Lichty BD; Brown EG; Sonenberg N; Bell JC
Journal
Journal of Virology, Vol. 74, No. 20, pp. 9580–9585
Publisher
American Society for Microbiology
Publication Date
October 15, 2000
DOI
10.1128/jvi.74.20.9580-9585.2000
ISSN
0022-538X