Journal article
Microscopic and Spectroscopic Analyses of Chlorhexidine Tolerance in Delftia acidovorans Biofilms
Abstract
The physicochemical responses of Delftia acidovorans biofilms exposed to the commonly used antimicrobial chlorhexidine (CHX) were examined in this study. A CHX-sensitive mutant (MIC, 1.0 μg ml(-1)) was derived from a CHX-tolerant (MIC, 15.0 μg ml(-1)) D. acidovorans parent strain using transposon mutagenesis. D. acidovorans mutant (MT51) and wild-type (WT15) strain biofilms were cultivated in flow cells and then treated with CHX at sub-MIC and …
Authors
Rema T; Lawrence JR; Dynes JJ; Hitchcock AP; Korber DR
Journal
Antimicrobial Agents and Chemotherapy, Vol. 58, No. 10, pp. 5673–5686
Publisher
American Society for Microbiology
Publication Date
October 2014
DOI
10.1128/aac.02984-14
ISSN
0066-4804