O001 Regulation of tissue remodelling by Oncostatin M in mouse lung is IL-6- and SMAD3-independent

IntroductionRemodeling of extracellular matrix (ECM) in lungs occurs with various chronic inflammatory conditions including idiopathic pulmonary fibrosis and allergic airway disease. Although TGFbeta/SMAD signaling and other molecules are recognized as important in controlling ECM deposition, the gp130 cytokine (or IL-6/LIF cytokine) family including Oncostatin M (OSM) and IL-6 have also been implicated. OSM is a potent regulator of ECM in …