Journal article
Impact of Treadmill Running and Sex on Hippocampal Neurogenesis in the Mouse Model of Amyotrophic Lateral Sclerosis
Abstract
Hippocampal neurogenesis in the subgranular zone (SGZ) of dentate gyrus (DG) occurs throughout life and is regulated by pathological and physiological processes. The role of oxidative stress in hippocampal neurogenesis and its response to exercise or neurodegenerative diseases remains controversial. The present study was designed to investigate the impact of oxidative stress, treadmill exercise and sex on hippocampal neurogenesis in a murine …
Authors
Ma X; Hamadeh MJ; Christie BR; Foster JA; Tarnopolsky MA
Journal
PLOS ONE, Vol. 7, No. 4,
Publisher
Public Library of Science (PLoS)
Publication Date
2012
DOI
10.1371/journal.pone.0036048
ISSN
1932-6203
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
8-Hydroxy-2'-DeoxyguanosineAmyotrophic Lateral SclerosisAnimalsBromodeoxyuridineCell ProliferationCell SurvivalDentate GyrusDeoxyguanosineDisease Models, AnimalExercise TestFemaleGene Expression RegulationHippocampusIntercellular Signaling Peptides and ProteinsMaleMiceNeurogenesisNeuronsOxidative StressPhenotypePhysical Conditioning, AnimalRNA, MessengerSex CharacteristicsTyrosine