Journal article
YAP enhances the pro‐proliferative transcriptional activity of mutant p53 proteins
Abstract
Mutant p53 proteins are present in more than half of human cancers. Yes‐associated protein (YAP) is a key transcriptional regulator controlling organ growth, tissue homeostasis, and cancer. Here, we report that these two determinants of human malignancy share common transcriptional signatures. YAP physically interacts with mutant p53 proteins in breast cancer cells and potentiates their pro‐proliferative transcriptional activity. We found YAP …
Authors
Di Agostino S; Sorrentino G; Ingallina E; Valenti F; Ferraiuolo M; Bicciato S; Piazza S; Strano S; Del Sal G; Blandino G
Journal
EMBO Reports, Vol. 17, No. 2, pp. 188–201
Publisher
Springer Nature
Publication Date
2 2016
DOI
10.15252/embr.201540488
ISSN
1469-221X
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Adaptor Proteins, Signal TransducingBreast NeoplasmsCDC2 Protein KinaseCell ProliferationCyclin ACyclin BCyclin-Dependent KinasesFemaleGene Expression Regulation, NeoplasticHCT116 CellsHumansMCF-7 CellsMutationPhosphoproteinsProtein BindingProtein TransportTranscription FactorsTumor Suppressor Protein p53YAP-Signaling Proteins