Journal article
Bisphosphonate Therapy for Reduced Bone Mineral Density During Treatment of Acute Lymphoblastic Leukemia in Childhood and Adolescence
Abstract
BACKGROUND: Osteopenia is a common consequence of the treatment of acute lymphoblastic leukemia (ALL) in children and adolescents, due predominantly to glucocorticosteroid therapy. The pathogenesis relates to an imbalance of resorption over formation of bone.
METHODS: Alendronate (Fosamax), an inhibitor of osteoclastic bone resorption, was administered for at least 6 months to 15 children with ALL during maintenance chemotherapy, after the …
Authors
Lethaby C; Wiernikowski J; Sala A; Naronha M; Webber C; Barr RD
Journal
Journal of Pediatric Hematology/Oncology, Vol. 29, No. 9, pp. 613–616
Publisher
Wolters Kluwer
Publication Date
9 2007
DOI
10.1097/mph.0b013e318142b7a1
ISSN
1077-4114