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Impact of ABCB1 and CYP2B6 Genetic Polymorphisms...

Journal article

Impact of ABCB1 and CYP2B6 Genetic Polymorphisms on Methadone Metabolism, Dose and Treatment Response in Patients with Opioid Addiction: A Systematic Review and Meta-Analysis

Abstract

BACKGROUND: Genetic variability may influence methadone metabolism, dose requirements, and risk of relapse. OBJECTIVES: To determine whether the CYP2B6*6 or ABCB1 (rs1045642) polymorphisms are associated with variation in methadone response (plasma concentration, dose, or response to treatment).

Authors

Dennis BB; Bawor M; Thabane L; Sohani Z; Samaan Z

Journal

PLOS ONE, Vol. 9, No. 1,

Publisher

Public Library of Science (PLoS)

DOI

10.1371/journal.pone.0086114

ISSN

1932-6203

Associated Experts

Lehana Thabane

Professor, Faculty of Health Sciences

Zainab Samaan

Professor (Part-Time), Faculty of Health Sciences

Labels

Fields of Research (FoR)

3214 Pharmacology and Pharmaceutical Sciences 32 Biomedical and Clinical Sciences 3202 Clinical Sciences

Medical Subject Headings (MeSH)

ATP Binding Cassette Transporter, Subfamily B ATP Binding Cassette Transporter, Subfamily B, Member 1 Analgesics, Opioid Aryl Hydrocarbon Hydroxylases Biotransformation Cytochrome P-450 CYP2B6 Databases, Bibliographic Drug Administration Schedule Drug Monitoring Haplotypes Homozygote Humans Methadone Opioid-Related Disorders Polymorphism, Genetic

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