Journal article
Outcomes of Dosage Adjustments Used to Manage Antiretroviral Drug Interactions
Abstract
Dosage adjustments are often used to manage HIV drug interactions, but little is known about their clinical significance. We examined patients from the Ontario HIV Cohort Study to assess the effects of dosage adjustments on plasma viral load. A significant reduction (0.67 log10 copies/mL) in viral load was associated with adjustments to manage efavirenz-based interactions (95% confidence interval, -1.33 to -0.01) but was not observed after …
Authors
Park-Wyllie LY; Levine MA; Holbrook A; Thabane L; Antoniou T; Yoong D; Kam D; Bayoumi AM
Journal
Clinical Infectious Diseases, Vol. 45, No. 7, pp. 933–936
Publisher
Oxford University Press (OUP)
Publication Date
October 1, 2007
DOI
10.1086/521252
ISSN
1058-4838