Differential Metabolomics for Quantitative Assessment of Oxidative Stress with Strenuous Exercise and Nutritional Intervention: Thiol-Specific Regulation of Cellular Metabolism with N-Acetyl-l-Cysteine Pretreatment

Despite several decades of active research, the success of large-scale clinical trials involving antioxidants remains equivocal given the complex biological interactions of reactive oxygen/nitrogen species in human health. Herein, we outline a differential metabolomics strategy by capillary electrophoresis-electrospray ionization-mass spectrometry (CE-ESI-MS) to assess the efficacy of nutritional intervention to attenuate oxidative stress …