Journal article
Biomarkers of browning of white adipose tissue and their regulation during exercise- and diet-induced weight loss 1 , 2
Abstract
BACKGROUND: A hypothesis exists whereby an exercise- or dietary-induced negative energy balance reduces human subcutaneous white adipose tissue (scWAT) mass through the formation of brown-like adipocyte (brite) cells. However, the validity of biomarkers of brite formation has not been robustly evaluated in humans, and clinical data that link brite formation and weight loss are sparse.
OBJECTIVES: We used rosiglitazone and primary adipocytes to …
Authors
Nakhuda A; Josse AR; Gburcik V; Crossland H; Raymond F; Metairon S; Good L; Atherton PJ; Phillips SM; Timmons JA
Journal
American Journal of Clinical Nutrition, Vol. 104, No. 3, pp. 557–565
Publisher
Elsevier
Publication Date
9 2016
DOI
10.3945/ajcn.116.132563
ISSN
0002-9165
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Adipocytes, BeigeAdipocytes, WhiteAdipose Tissue, BeigeAdultAnimalsBiomarkersCells, CulturedCombined Modality TherapyDiet, ReducingExerciseFemaleGene Expression ProfilingGene Expression RegulationHumansHypoglycemic AgentsMice, 129 StrainMice, Inbred C57BLOverweightRNA, MessengerSubcutaneous FatUncoupling Protein 1Weight Loss