Journal article
Hippocampal damage in mouse and human forms of systemic autoimmune disease
Abstract
Systemic lupus erythematosus (SLE) is frequently accompanied by neuropsychiatric (NP) and cognitive deficits of unknown etiology. By using autoimmune MRL-lpr mice as an animal model of NP-SLE, we examine the relationship between autoimmunity, hippocampal damage, and behavioral dysfunction. Fluoro Jade B (FJB) staining and anti-ubiquitin (anti-Ub) immunocytochemistry were used to assess neuronal damage in young (asymptomatic) and aged (diseased) …
Authors
Ballok DA; Woulfe J; Sur M; Cyr M; Sakic B
Journal
Hippocampus, Vol. 14, No. 5, pp. 649–661
Publisher
Wiley
Publication Date
January 2004
DOI
10.1002/hipo.10205
ISSN
1050-9631
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AgingAnimalsChoroid PlexusCyclophosphamideDisease Models, AnimalFemaleFluoresceinsFluorescent DyesGliosisHippocampusHumansImmunohistochemistryImmunosuppressive AgentsLearning DisabilitiesLupus Vasculitis, Central Nervous SystemMaleMaze LearningMemory DisordersMiceMice, Inbred MRL lprMiddle AgedNerve DegenerationNeuronsOrganic ChemicalsT-Lymphocytesfas Receptor