Journal article
A Long-Term High-Carbohydrate Diet Causes an Altered Ontogeny of Pancreatic Islets of Langerhans in the Neonatal Rat
Abstract
Neonatal rats fed a high-carbohydrate (HC) formula by gastrostomy are hyperinsulinemic but normoglycemic. We determined whether HC formula altered pancreatic islet cell ontogeny. Rats were reared from d 4 on an HC formula or a high-fat formula, or were allowed to suckle naturally, and the pancreata were examined histologically from animals ≤24 d of age. The mean area of individual islets was reduced, but islet number was increased in HC rats …
Authors
Petrik J; Srinivasan M; Aalinkeel R; Coukell S; Arany E; Patel MS; Hill DJ
Journal
Pediatric Research, Vol. 49, No. 1, pp. 84–92
Publisher
Springer Nature
Publication Date
1 2001
DOI
10.1203/00006450-200101000-00019
ISSN
0031-3998