Journal article
Testing for heterogeneity among the components of a binary composite outcome in a clinical trial
Abstract
BackgroundInvestigators designing clinical trials often use composite outcomes to overcome many statistical issues. Trialists want to maximize power to show a statistically significant treatment effect and avoid inflation of Type I error rate due to evaluation of multiple individual clinical outcomes. However, if the treatment effect is not similar among the components of this composite outcome, we are left not knowing how to interpret the …
Authors
Pogue J; Thabane L; Devereaux P; Yusuf S
Journal
BMC Medical Research Methodology, Vol. 10, No. 1,
Publisher
Springer Nature
Publication Date
December 2010
DOI
10.1186/1471-2288-10-49
ISSN
1471-2288