Journal article
Mendelian randomization of blood lipids for coronary heart disease
Abstract
AIMS: To investigate the causal role of high-density lipoprotein cholesterol (HDL-C) and triglycerides in coronary heart disease (CHD) using multiple instrumental variables for Mendelian randomization.
METHODS AND RESULTS: We developed weighted allele scores based on single nucleotide polymorphisms (SNPs) with established associations with HDL-C, triglycerides, and low-density lipoprotein cholesterol (LDL-C). For each trait, we constructed two …
Authors
Holmes MV; Asselbergs FW; Palmer TM; Drenos F; Lanktree MB; Nelson CP; Dale CE; Padmanabhan S; Finan C; Swerdlow DI
Journal
European Heart Journal, Vol. 36, No. 9, pp. 539–550
Publisher
Oxford University Press (OUP)
Publication Date
March 1, 2015
DOI
10.1093/eurheartj/eht571
ISSN
0195-668X