Conference
Endurance Exercise Rescues Cardiomyopathy in Mitochondrial DNA Mutator Mouse Model of Aging
Abstract
A causal role for mitochondrial DNA (mtDNA) mutagenesis in the etiology of age associated cardiomyopathy is supported by the polymerase gamma (PolG) mutator mouse, harbouring a proofreading‐deficient copy of PolG, which exhibits cardiac hypertrophy, mitochondrial dysfunction in cardiomyocytes, and reduced lifespan. Longitudinal studies demonstrate that endurance (END) training reduces risk of cardiovascular diseases and extends life expectancy. …
Authors
Safdar A; Ogborn DI; Bourgeois JM; Melov S; Hubbard A; Hettinga BP; Kujoth GC; Prolla TA; Tarnopolsky MA
Volume
24
Pagination
pp. 619.17-619.17
Publisher
Wiley
Publication Date
April 2010
DOI
10.1096/fasebj.24.1_supplement.619.17
Conference proceedings
The FASEB Journal
Issue
S1
ISSN
0892-6638