Journal article
Effects of benralizumab on airway eosinophils in asthmatic patients with sputum eosinophilia
Abstract
BACKGROUND: Many asthmatic patients exhibit sputum eosinophilia associated with exacerbations. Benralizumab targets eosinophils by binding IL-5 receptor α, inducing apoptosis through antibody-dependent cell-mediated cytotoxicity.
OBJECTIVES: We sought to evaluate the safety of benralizumab in adults with eosinophilic asthma and its effects on eosinophil counts in airway mucosal/submucosal biopsy specimens, sputum, bone marrow, and peripheral …
Authors
Laviolette M; Gossage DL; Gauvreau G; Leigh R; Olivenstein R; Katial R; Busse WW; Wenzel S; Wu Y; Datta V
Journal
The Journal of Allergy and Clinical Immunology, Vol. 132, No. 5, pp. 1086–1096.e5
Publisher
Elsevier
Publication Date
November 2013
DOI
10.1016/j.jaci.2013.05.020
ISSN
0091-6749