P134 Methacholine challenge to demonstrate therapeutic equivalence of terbutaline via different turbuhaler devices in patients with mild to moderate asthma: appraisal of a phase iii, four-way crossover design

To demonstrate therapeutic equivalence of terbutaline via two different Turbuhaler® devices by evaluating its protective effect against methacholine-induced bronchoconstriction in patients with stable asthma. In this double-blind, double-dummy, multicentre, single-dose, 4-way crossover study, patients with stable, mild-to-moderate asthma (FEV1 ≥ 80% predicted normal) were randomised to 0.5 or 1.5 mg terbutaline via either Turbuhaler® M3 or M2 …