Journal article
REVIEW ARTICLE: HIV Infection in the Female Genital Tract: Discrete Influence of the Local Mucosal Microenvironment
Abstract
Women acquire HIV infections predominantly at the genital mucosa through heterosexual transmission. Therefore, the immune milieu at female genital surfaces is a critical determinant of HIV susceptibility. In this review, we recapitulate the evidence suggesting that several distinctive innate immune mechanisms in the female genital tract (FGT) serve to significantly deter or facilitate HIV-1 infection. Epithelial cells lining the FGT play a key …
Authors
Kaushic C; Ferreira VH; Kafka JK; Nazli A
Journal
American Journal Of Reproductive Immunology, Vol. 63, No. 6, pp. 566–575
Publisher
Wiley
Publication Date
June 2010
DOI
10.1111/j.1600-0897.2010.00843.x
ISSN
1046-7408