Journal article
Pituitary Adenylate Cyclase-Activating Peptide as a Neurotransmitter in the Canine Ileal Circular Muscle 1
Abstract
Pituitary adenylate cyclase-activating peptide (PACAP)1-27, PACAP1-38, and vasoactive intestinal peptide (VIP) initiated dose-dependent contractions of canine ileal circular muscle after intra-arterial injection in vivo or ex vivo. PACAP1-27- and VIP-induced contractions approached the tissue maximum; VIP was 100-fold less potent. PACAP1-38 was more potent than VIP. PACAP1-27 contractions in vivo were unaffected by hexamethonium, reduced …
Authors
Fox-Threlkeld J-AET; McDonald TJ; Woskowska Z; Iesaki K; Daniel EE
Journal
Journal of Pharmacology and Experimental Therapeutics, Vol. 290, No. 1, pp. 66–75
Publisher
Elsevier
Publication Date
July 1999
DOI
10.1016/s0022-3565(24)34869-4
ISSN
0022-3565