Journal article
Bmi1 promotes prostate tumorigenesis via inhibiting p16INK4A and p14ARF expression
Abstract
We report here that the polycomb group protein Bmi1 promotes prostate tumorigenesis. Bmi1 is detected at higher levels in androgen-independent PC3 and DU145 than in androgen-dependent LNCaP prostate cancer (CaP) cells. Ectopic Bmi1 enhanced the expression of human telomerase reverse transcriptase (hTERT) and suppressed the exression of p16(INK4A) and p14(ARF) in CaP cells. Consistent with these observations, immunohistochemical staining of 51 …
Authors
Fan C; He L; Kapoor A; Gillis A; Rybak AP; Cutz J-C; Tang D
Journal
Biochimica et Biophysica Acta, Vol. 1782, No. 11, pp. 642–648
Publisher
Elsevier
Publication Date
November 2008
DOI
10.1016/j.bbadis.2008.08.009
ISSN
0006-3002