Journal article
Effect of a leukotriene B4 receptor antagonist SC-53228 on ozone-induced airway hyperresponsiveness and inflammation in dogs.
Abstract
The importance of the potent neutrophil chemoattractant leukotriene (LT)B4 in causing ozone-induced bronchoconstriction, airway inflammation, and airway hyperresponsiveness in dogs was studied using the LTB4-receptor antagonist SC-53228. Seven dogs from random sources were studied three times, at least 2 wk apart. On each occasion, acetylcholine (Ach) airway responsiveness was measured before and 1 h after ozone (3 ppm, 30 min) or dry air …
Authors
Stevens WH; Vanderheyden C; Wattie J; Lane CG; Smith W; O'Byrne PM
Journal
American Journal of Respiratory and Critical Care Medicine, Vol. 152, No. 5, pp. 1443–1448
Publisher
Oxford University Press (OUP)
Publication Date
November 1995
DOI
10.1164/ajrccm.152.5.7582275
ISSN
1073-449X