Journal article
Enterochromaffin cell and 5-hydroxytryptamine responses to the same infectious agent differ in Th1 and Th2 dominant environments
Abstract
BACKGROUND/AIM: 5-Hydroxytryptamine (5-HT) released from enterochromaffin cells influences intestinal homeostasis by altering gut physiology and is implicated in the pathophysiology of various gut disorders. The mechanisms regulating 5-HT production in the gut remain unclear. This study investigated the T helper (Th) 1/Th2-based immunoregulation of enterochromaffin cell function and 5-HT production in a model of enteric infection.
METHODS AND …
Authors
Motomura Y; Ghia J-E; Wang H; Akiho H; El-Sharkawy RT; Collins M; Wan Y; McLaughlin JT; Khan WI
Journal
Gut, Vol. 57, No. 4,
Publisher
BMJ
Publication Date
April 2008
DOI
10.1136/gut.2007.129296
ISSN
0017-5749