Journal article
Kinase inhibitors modulate huntingtin cell localization and toxicity
Abstract
Phosphorylation of the Huntington's disease protein Htt by CK2 leads to Htt nuclear translocation in response to stress. Inhibition of other kinase pathways can restore phosphorylation to hypophosphorylated Htt in Huntington's disease and may lead to a therapeutic strategy.
Authors
Atwal RS; Desmond CR; Caron N; Maiuri T; Xia J; Sipione S; Truant R
Journal
Nature Chemical Biology, Vol. 7, No. 7, pp. 453–460
Publisher
Springer Nature
Publication Date
7 2011
DOI
10.1038/nchembio.582
ISSN
1552-4450
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsBlotting, WesternCasein Kinase IICell LineCell NucleusCell SurvivalDisease Models, AnimalEndoplasmic ReticulumFluorescent Antibody TechniqueHuntingtin ProteinHuntington DiseaseI-kappa B KinaseMiceMutationNerve Tissue ProteinsNuclear ProteinsPhosphorylationProtein Kinase InhibitorsSerineSpindle ApparatusTransfection